Job number: 1204378
Position Title: Senior Scientist, PD/Biomarker
Company: 1881 EMD Serono, Inc.
Location: United States
Date: 11.04.2013
EMD Serono, Inc. is a leader in the U.S. biopharmaceutical industry. We have more than 1,000 employees throughout the United States with fully
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PURPOSE OF THE ROLE:
1. Lead a team of technicians aiming to develop, maintain, and provide expertise in rodent PK/PD biomarker studies and conceptual inflammation models.
2. Establish PK/PD and conceptual inflammation models querying disease mechanisms, clinical readouts, and complex biomarkers translatable to patients. Build database of reference treatments in disease models.
3. Proficient in technologies useful in biomarker determination including flow cytometry, QPCR, luminex, ELISA etc.
4. Propose, execute, and present results of innovative experiments. Provide written and oral presentations of results to members of the immunology group and project teams. Provide decision-enabling pharmacological data supporting the advancement of discovery projects from DPLO to DP1.
5. Contribute to the recognition of Merck Serono as a global player in the field of Immunology by scientific publications.
6. Serve on internal discovery project teams as team member. Support in-licensing efforts and contribute to Due Diligence upon request.
KEY TASKS & RESPONSIBILITIES:
- Support specific projects by providing expertise in in vivo pharmacology of PK/PD and conceptual models of inflammation.
- Validate pathways and biomarkers in conceptual models with a strong focus on markers translatable to the clinical setting.
- Conduct original research contributing to the recognition of Merck Serono in the scientific community. Publish scientific work in peer-reviewed journals.
- Design, execute, analyze, and present results of innovative experiments
- Evaluate and implement innovative technologies for solving scientific questions and maximizing the gain of information from pharmacological models.
- Direct management of 2-3 associate scientists or research associates. Develop and recommend objectives of direct reports.
- Write animal protocols and ensure adherence to animal welfare guidelines.
- Ensure adherence to quality standards as well as proper documentation of experimental results.
- Build and maintain strong network of academic experts.
- Propose new targets / Evaluate external opportunities. Detect, recognize and communicate trends/events outside the company which will alter the direction of a therapeutic area/technology.
- Have a thorough understanding of the strategic importance of Research projects and their direct impact on the company’s success. Have a good overview of the R&D pipeline.
- Be responsible for implementing and maintaining a state-of-the-art laboratory environment.
INTERNALLY :
- Intra-Therapeutic Area (TA) interactions: Exploratory Immunology, Cellular Immunology, and Clinical Immunology.
- Inter TA interactions: Project teams, LDT, Toxicology, DMPK, NBE-Tech, NCE-Tech etc.
- Clinical development and Business Development.
EXTERNALLY :
CRO Academic collaborators and network of scientific experts
EDUCATION & LANGUAGES:
- Degree: PhD or MD/PhD in immunology with considerable basic research experience.
- Excellent knowledge of written and spoken English.
PROFESSIONAL SKILLS & EXPERIENCE:
Thorough understanding of innate and adaptive immunology with focus on adaptive or innate immunology. Hands-on experience in running conceptual models of inflammation relevant to T and B cell activation and innate immune mechanisms.
- Strong technical expertise and hands-on experience in in vitro and in vivo immunological methods as well as flow cytometry, molecular biology, and biochemical techniques.
- Experience with inflammation-induced kidney damage a plus.
- Capable of teaching relevant techniques to research associates.
- 3-5 years of postdoctoral experience in academia or pharmaceutical setting.
- Excellent academic network
- Track record of scientific publications
- Track record of establishing new immunological models and methods
PERSONAL SKILLS & COMPETENCIES:
- Innovative thinking approach, excellent communication skills.
- Experience in managing research associates or students a plus
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